Will Citicoline Powder boost cognitive performance?

1.What is Citicoline?

Citicoline is a brain chemical that occurs naturally in the body. It's in dietary supplements in the US, but was originally a prescription drug in Japan.

Citicoline seems to increase a brain chemical called phosphatidylcholine. Citicoline might also increase the amounts of other chemicals that send messages in the brain. It was originally used as a drug to help improve memory and brain function after a stroke.

People use citicoline for age-related decline in memory and thinking, glaucoma, stroke, Alzheimer disease, bipolar disorder, depression, and many other conditions, but there is no good scientific research to support most of these uses.

Don't confuse citicoline with choline or phosphatidylcholine. These are not the same.

 Choline vs Phosphatidylcholine.

2. Citicoline health benefits

Age-Related Cognitive Decline

Citicoline supplementation improved memory in older adults with age-associated memory impairment compared to a placebo (no treatment) group. However, the study is not generalizable to young adults or people with cognitive diseases like dementia and Alzheimer's disease (AD).

A review of a collection of studies showed a positive effect of citicoline on cognitive function in people with mild vascular cognitive impairment, vascular dementia, or AD. Because citicoline was used with the standard treatment (acetylcholinesterase inhibitor) for AD, the effect of citicoline alone on AD is unclear.

Cognitive Enhancement

In a study, a citicoline-caffeine-based drink improved attention, mental alertness, and memory.Since citicoline was combined with caffeine, it is unclear what the effect of citicoline alone is on attention and memory.

Based on a study in young, healthy males, citicoline improved motor function and attention after four weeks of supplementation. However, study results might not apply to populations other than young, healthy males.

Eye Surgery Recovery

Using citicoline eye drops three times a day for one month after eye surgery aided the recovery of corneal sensitivity after LASIK (laser-assisted in situ keratomileusis).

Stroke Treatment

A systematic review of studies found citicoline alone benefited acute ischemic stroke (blood clots in the brain). However, citicoline offers limited benefits on top of standard stroke treatment with rtPA or recombinant tissue plasminogen activator (clot-busting drug).

Furthermore, one study in people with a first ischemic stroke showed that after the stroke, people who received citicoline over two years had reduced cognitive impairment.

3.How to use?

Citicoline powder is available as a single supplement or as one ingredient in some supplements marketed to promote brain health. Typical doses are 250–1,000 mg/day. According to the European Food Safety Authority, the recommended maximum daily dose of citicoline is 500 mg/day for supplements and 1,000 mg/day for medical foods in middle-aged to elderly adults. For healthy individuals, lower doses (e.g. 250 mg/day) may provide more benefit than higher doses , while most clinical studies in patients with neurological disease used doses of 1,000 mg/day. In dementia patients, treatment for at least 12 months was generally required to see evidence of cognitive benefit.

4.What food may contain citicoline？

Besides supplementation, another way to increase citicoline levels is by consuming cytidine- and choline-rich foods. Citicoline is composed of cytidine and choline.20 Cytidine is found in meat, especially organ meats.

Foods rich in choline include the following:
Beef liver, pan-fried, 3 ounces (356 mg per serving)
Egg, hard-boiled, 1 large egg (147 mg per serving)
Beef top round, separable lean only, braised, 3 ounces (117 mg per serving)
Chicken breast, roasted, 3 ounces (72 mg per serving)
Beef, ground, 93% lean meat, broiled, 3 ounces (72 mg per serving)
Fish, cod, Atlantic, cooked, dry heat, 3 ounces (71 mg per serving)
Beans, kidney, canned, one-half cup (45 mg per serving)
Quinoa, cooked, 1 cup (43 mg per serving)
Brussels sprouts, boiled, one-half cup (32 mg per serving)
Broccoli, chopped, boiled, drained, one-half cup (31 mg per serving)

5.Where can I buy citicoline powder?

If you want to buy citicoline powder bulk goods, please send your information to ericyang@xasost.com email, we will reply you as soon as possible.

References
1.Bruce SE, Werner KB, Preston BF, et al. Improvements in concentration, working memory and sustained attention following consumption of a natural citicoline-caffeine beverage. Int J Food Sci Nutr. 2014;65(8):1003-1007. doi:10.3109/09637486.2014.940286

2.McGlade E, Agoston AM, DiMuzio J, et al. The effect of citicoline supplementation on motor speed and attention in adolescent males.J Atten Disord. 2019;

3.Cinar E, Yuce B, Aslan F, Erbakan G. Neuroprotective effect of citicoline eye drops on corneal sensitivity after LASIK. J Refract Surg. 2019;35(12):764-770. doi:10.3928/1081597X-20191021-01

4.Secades JJ, Alvarez-Sabín J, Castillo J, et al. Citicoline for acute ischemic stroke: a systematic review and formal meta-analysis of randomized, double-blind, and placebo-controlled trials. J Stroke Cerebrovasc Dis. 2016;25(8):1984-1996. doi:10.1016/j.jstrokecerebrovasdis.2016.04.010

5.https://dpointernational.com/question/what-is-the-difference-between-phosphatidylcholine-and-choline/