What are the benefits of taking fisetin?

1.What is Fisetin?

Fisetin is a special kind of polyphenol known to deliver various longevity benefits in cell and animal-based studies. Specifically, fisetin is a flavonoid, a unique class of polyphenols that is believed to prevent disease and encourage healthy aging through potent antioxidant and anti-inflammatory effects.

Perhaps most exciting is fisetin's ability to function as a senolytic, a compound that may extend lifespan and prevent age-related disease by promoting natural cellular senescence.

There are a variety of foods that naturally contain fisetin. Strawberries, apples, and kiwis are a few of the most common. Though delicious, these foods do not contain enough fisetin to mirror the dosages used in studies.

Supplementation is likely the best way to increase intake of fisetin, although it comes with caveats

Compared to other well-known sources of polyphenols and flavonoids like green tea extract and red wine, fisetin has only just recently caught the attention of the scientific community.

Animal and cell culture studies already indicate fisetin is a powerful anti-inflammatory, anti-cancer, and immune supporting compound.

Few human studies have been conducted to date. However, researchers are actively pursuing several studies to better understand fisetin’s role in promoting longevity and extending lifespan.

For example, researchers at the Mayo Clinic in Rochester, Minnesota, are launching several studies at the time of this writing. Most exciting, the clinic plans to investigate the use of fisetin to prevent or reduce symptoms of COVID-19.

The primary mechanisms of action for fisetin include reducing oxidative damage within cells, enhancing existing antioxidants, blocking the NF-KB pathway to reduce inflammation, and blocking the mTOR pathway to promote longevity.

Related Products: Fisetin Powder

2.What Foods Contain Fisetin?

According to a 2013 study published by the peer-reviewed medical journal, Antioxidants and Redox Signaling, the highest concentrations of fisetin can be found in the foods below:

Strawberries: 160μg fisetin per gram

Apples: 26.9μg fisetin per gram

Persimmons: 10.6μg fisetin per gram

Lotus Root: 5.8μg fisetin per gram

Onion: 4.8μg fisetin per gram

Grapes: 3.9μg fisetin per gram

Kiwis: 2.0μg fisetin per gram

Peaches: 0.6μg fisetin per gram

Cucumbers: 0.1μg fisetin per gram

Authors note that concentrations were measured from freeze-dried food samples. Actual concentrations of fisetin may vary depending on where produce is grown, and how it is harvested, transported, prepared, and consumed.

Authors do not note exactly what kind of apples were measured. This is problematic, given the study was conducted in Iwate, Japan. Iwate is the country’s 3rd largest producer of apples, growing at least 5 different varieties.

Due to unique pigmentation and nutrient content, fisetin concentrations are likely to vary across each: Fuji, Shinano Gold, Jonagold, Fuyukoi, and Orin.

3.The Benefits Of Fisetin

Studies indicate that fisetin acts as a kind of metabolism control switch. This may help your body maintain healthy glucose levels and can positively affect your kidney health and vision health.

• Fisetin Powder may have ability to beat senescent cells, which have ceased dividing
• Fisetin helps save the brain from age-related damage, improving cognitive function
• Fisetin's anti-inflammatory effects help reduce inflammation throughout the body
• A powerful antioxidant, supporting cells from oxidative damage, especially with age
• Fisetin is a natural substance found in strawberries and apples.
• Can a single compound really slow down the clock? In multiple organisms, the answer is yes, thanks to fisetin.
• As we age, our cells undergo a subtle shift: once healthy, some begin to disrupt their neighbors, impairing overall function. Fisetin helps restore balance by reducing the presence of these troublesome cells, supporting healthier cellular activityFisetin seems to be better than Quercetin in killing senescent cells.
• Memory and cognitive performance get a welcome upgrade thanks to fisetin, which packs a punch when it comes to brain benefits.
• Fisetin inhibits the mTOR pathway. mTOR accelerates aging.
• Fisetin improves skin health, for example by reducing the production of metalloproteinases which are enzymes that break down collagen and elastin.

4.How Does It Work?

Polyphenols like fisetin are known to improve health by causing a cascade of positive activities on the cellular level. This is especially true of flavonoids, the largest sub-class of polyphenols that are most widely considered to be the chief activators of antioxidant potential from plants.

As explained in a 2016 overview of flavonoids published by the Journal of Nutritional Science, flavonoids are known to have an anti-oxidative, anti-inflammatory, anti-carcinogenic, and anti-mutagenic impact on cellular function.

When it comes to flavonoids, fisetin shows exceptional promise. This plant compound has already demonstrated great potential to ward off disease and promote healthy aging in cell-based and animal studies. These studies have identified at least three core mechanisms of action.

Conclusion

Fisetin compound goes beyond its antioxidant benefits—fisetin also offers notable anti-inflammatory effects. Backed by scientific research, its benefits are more than promising: supporting brain function, enhancing overall wellness, and strengthening your defenses against disease.

Sost biotech supply large quantities of fisetin powder 99%, welcome to inquire~

References

https://novoslabs.com/novos-anti-aging-longevity-supplement/fisetin-anti-aging-supplement-longevity/?srsltid=AfmBOopbbCey9Fb2-JopCxiEZ36tcRI-K62x3h-RiK2tmQ6kIAH2WaTh

https://vitality-pro.com/fisetin/benefits-dosage-side-effects-fis/