Is Pterostilbene better than Resveratrol?

Pterostilbene Introduction

Pterostilbene, also known as trans-3,5-dimethoxy-4-hydroxystilbene, is a natural polyphenol found in plants. It belongs to the group of stilbenes, which are key antioxidants in blueberries and play an important role in the plant's defense against antimicrobial and antioxidant functions.

According to domestic and international studies, Pterostilbene is considered to be one of the most versatile whitening and anti-aging cosmetic ingredients, as it possesses a variety of skincare benefits, including whitening, antioxidant, anti-inflammatory, anti-glycation, defense against UV damage, as well as firming and anti-wrinkle. It is considered one of the most versatile whitening and anti-aging cosmetic ingredients. No other natural plant ingredient has yet been found to surpass its effectiveness, which is why Rosewood Pterostilbene is also known as the “king of plant whitening and antioxidant".

Is Pterostilbene better than Resveratrol?

Numerous studies have shown that Pterostilbene has superior health benefits compared to resveratrol, which is why it has been dubbed "the better resveratrol". While resveratrol has been extensively studied, Pterostilbene is a promising alternative due to its superior bioavailability and metabolic stability.

Bioavailability and metabolic stability: Astragalus has a significantly higher bioavailability than resveratrol, which means that it remains active in the body for a longer period of time and is able to exert its biological effects more effectively. In addition, the lower metabolic rate of astragalus allows it to remain in the body for a longer period of time and is less likely to be cleared rapidly.

Stability: Astragalus is more environmentally stable and remains active for a longer period of time, even in skincare products, whereas resveratrol has a weaker chemical structure and is prone to break down under the influence of environmental factors.

Pterostilbene in Cosmetics Effects

(1) Whitening Pterostilbene has excellent melanin and complex enzyme inhibiting effects. Studies have shown that Pterostilbene inhibits melanogenesis, melanocyte dendrites and melanosome transportation through the cAMP/PKA/CREB pathway. The IC50 value of its half inhibitory concentration on tyrosinase is significantly better than that of common whitening ingredients such as vitamin C and arbutin, and only slightly lower than that of glycyrrhizin, which is regarded as “whitening gold”. Compared with other whitening ingredients such as glycyrrhizin, tretinoin and vitamin C, Pterostilbene has the most significant melanin inhibiting effect. In addition, Pterostilbene can also promote cell autophagy and effectively metabolize melanin and lipofuscin that have already been generated in the skin, so its whitening speed is more rapid than that of other whitening ingredients.

(2) Antioxidant Similar to resveratrol, Pterostilbene also shows excellent antioxidant effect. In the DPPH free radical scavenging test, Pterostilbene demonstrated a strong ability to inhibit DPPH free radicals. In addition, it was found that Pterostilbene not only displays direct antioxidant effects, but also regulates antioxidant enzymes and antioxidant defense systems throughout the body.

(3) Anti-inflammatory Pterostilbene purpurascens can effectively inhibit the expression of inflammatory factors such as COX-2, PGE2 and NO through the regulation of Nrf2 pathway, showing excellent anti-inflammatory effects. At the same time, Pterostilbene can also reduce intracellular inflammatory responses and reactive oxygen species (ROS) levels, and inhibit the activation of neutrophils, the production of inflammatory mediators, and the apoptosis of endothelial cells.

(6) Firming and anti-wrinkle elastase and collagenase can damage the skin structure, leading to skin laxity and wrinkles. And Pterostilbene has the effect of inhibiting the activity of elastase (IC50=50 μg/mL) and collagenase (IC50=125 μg/mL). In a human experiment, the continuous use of a cream containing 0.4% Pterostilbene in the morning and evening for 8 weeks resulted in a significant improvement in wrinkles and fine lines as well as skin elasticity in the subjects.

Where can I buy pterostilbene powder?

As a ISO 9001-certified manufacturer, Xi'an Sost Biotech produces cosmetic-grade Pterostilbene powder with:

• Purity: ≥98% (HPLC verified)

• Particle size: 80-120 mesh (optimized for bioavailability)

• Certifications: Kosher, Halal, Non-GMO

Contact us today for: Sample requests、OEM formulation support

Email:ericyang@xasost.com