Is niacinamide beneficial during pregnancy?

Is niacinamide beneficial during pregnancy?

Nicotinamide powder(vitamin B3) is an essential water-soluble vitamin involved in energy metabolism, DNA repair, and cell signaling. For pregnant women, moderate niacinamide intake may offer the following benefits:

Supporting fetal nervous system development
A cohort study of 497 pregnant women at the University of Southampton in the UK found that newborns whose mothers had higher serum niacinamide levels during pregnancy had slightly higher neurobehavioral developmental scores at 12 months of age.

Reducing skin concerns during pregnancy
Hormonal fluctuations during pregnancy often lead to dry, dull, or inflammatory rashes. Niacinamide can relieve itching and redness by strengthening the skin barrier and reducing transepidermal water loss.

Assisting with blood sugar and lipid regulation
Animal studies suggest that niacinamide can improve insulin sensitivity and may have potential benefits for pregnant women with gestational diabetes.
However, "beneficial" does not necessarily mean "more is better." The Chinese Dietary Guidelines recommend that pregnant women limit their daily niacinamide intake to 14–18 mg. If supplementing with a multivitamin, the total daily intake should not exceed 35 mg to avoid adverse reactions such as facial flushing and elevated liver enzymes.

Is niacinamide safe for infants?

Placental transport and breast milk secretion
Pharmacological data show that pure niacinamide powder is actively transported across the placenta, with fetal umbilical cord blood concentrations typically higher than maternal levels. Trace amounts can also be detected in breast milk during lactation, but there is no evidence that normal doses pose a risk to infants.

Safety of topical skincare products

Dermatologists agree that creams or serums containing less than 5% niacinamide have a transdermal absorption rate of less than 0.5%, virtually no niacinamide enters the systemic circulation, and the effects on the fetus are negligible. Clinical observations have also not found a link between topical niacinamide use during pregnancy and birth defects.

Precautions

Some pregnant women with sensitive constitutions may develop contact dermatitis, manifesting as erythema and stinging. A 24-hour patch test behind the ear or on the inner forearm is recommended before first use.
In summary, under a doctor's guidance, regular doses of niacinamide, taken through diet or approved skincare products, are considered safe for fetuses and breastfeeding infants.

Can niacinamide help treat eczema?

High niacinamide powder levels during pregnancy reduce the risk of infant eczema.
A study from the University of Southampton showed that infants born to mothers whose serum niacinamide levels during pregnancy were in the upper tertile had an approximately 30% lower risk of atopic eczema within 12 months of age. This mechanism may be that niacinamide promotes ceramide synthesis, strengthens the fetal skin barrier, and reduces transdermal penetration of allergens after birth.

Adjunctive treatment for eczema in infants, children, and adults
Niacinamide has anti-inflammatory effects, inhibits mast cell degranulation, and repairs stratum corneum lipids. Multiple randomized controlled trials have demonstrated that daily oral administration of 500–1000 mg of niacinamide (weight-based for infants and young children) significantly reduces the EASI score in mild to moderate atopic dermatitis and reduces the need for topical hormones.

Recommendations
• During pregnancy: Prioritize dietary sources of niacinamide (chicken, salmon, peanuts, mushrooms) and avoid high-dose oral supplements.
• Infants and young children: If oral administration is necessary, choose drops or granules under the guidance of a pediatrician and monitor liver function.
• Topical: 2%–5% niacinamide cream can be used as a hormone replacement or dose reduction regimen, twice daily for 4–8 weeks.

Where can I buy niacinamide powder wholesale?

Niacinamide powder is a pharmaceutical/cosmetic-grade raw material. Contact sost biotech, a professional cosmetic raw material supplier.

• We offer cosmetic-grade 99% purity niacinamide, with a minimum order quantity typically of 25 kg and third-party microbiological testing.

• Purity ≥ 99.5%, suitable for high-end skincare products, free sampling available.• Food-grade products require a SC certificate, while cosmetic-grade products require a COA, MSDS, and seven heavy metal tests.

• Transportation and Storage: Store in a 25 kg aluminum foil bag + cardboard drum in a cool, dry place away from light to prevent moisture absorption and clumping.

•Email:ericyang@xasost.com