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Do fisetin supplements work?
1.What is Fisetin?
Fisetin is a special kind of polyphenol known to deliver various longevity benefits in cell and animal-based studies. Specifically, fisetin is a flavonoid, a unique class of polyphenols that is believed to prevent disease and encourage healthy aging through potent antioxidant and anti-inflammatory effects.
Perhaps most exciting is fisetin’s ability to function as a senolytic, a compound that may extend lifespan and prevent age-related disease by promoting natural cellular senescence.
There are a variety of foods that naturally contain fisetin. Strawberries, apples, and kiwis are a few of the most common. Though delicious, these foods do not contain enough fisetin to mirror the dosages used in studies.
The table below lists some of the common dietary sources of fisetin.
| Food | Fisetin amount (micrograms/gram) |
| Peach | 0.6 |
| Cucumber | 0.14 |
| Kiwi | 2.0 |
| Onion | 4.8 |
| Apple | 26.9 |
| Strawberry | 160 |
Fisetin is also available as a supplement, which contains much higher dosages, typically within a range of 100–500 mg, compared to food sources. This is important to keep in mind when considering supplementation with fisetin.
2.Potential fisetin health benefits
Although most of the research about the health benefits of fisetin has been conducted in animals, these studies do show promising results that suggest the compound may be beneficial if validated in human studies in the future.
Fisetin and aging
Fisetin Powder may potentially contribute to longevity. Studies in mice have shown some benefits in the aging process. Since it can work as an antioxidant and is also reported to reduce the number of senescent cells, it is proposed to help slow down aging and reduce the risk of age-related health decline. However, no clinical studies have been conducted in humans to confirm long-term fisetin’s impact on aging. Fisetin and Alzheimer's and dementia
Fisetin may help manage neurodegenerative diseases such as Alzheimer’s and dementia. Studies conducted mostly in mice have shown that fisetin decreases oxidative stress and reduces neural cell death, which can be important for slowing the progression of these conditions. Fisetin and cancer
Fisetin is proposed to help prevent cancer, and it's believed to help treat cancer. It is thought to work on multiple pathways to reduce inflammation, potentiate cell death, and prevent the growth of new blood vessels that could allow tumors to grow.
When combined, fisetin is reported to have a synergetic effect with some anticancer agents. However, studies evaluating fisetin for cancer have been mostly conducted in cell culture studies, and more data in humans is necessary.
Fisetin and diabetes
Fisetin has also demonstrated an anti-diabetic effect in some animal studies. It has been associated with lowering blood glucose levels and Hemoglobin A1c, a measure of a person’s average blood sugar level over the previous three months. Additionally, it may also be beneficial in the management of diabetic neuropathy.
Fisetin and UV-A damage
UV-A is a type of ultraviolet light produced by the sun that can cause skin damage. It is associated with numerous age-related conditions of the skin, such as the development of premature wrinkles, damage to collagen and elastin, and increased risk of skin cancer. Fisetin is proposed to reduce these effects of UV-A.
Fisetin is believed to use two mechanisms to repair and prevent UV-A damage: neutralizing free radicals and reducing the production of matrix metalloproteinase enzymes. The neutralization of free radicals prevents them from damaging healthy skin cells. Matrix metalloproteinase enzymes break down the collagen and elastin found in healthy skin, and by reducing levels, fisetin may help improve skin structure.
Fisetin and stroke
Acute ischemic stroke is a leading cause of death and disability in the United States, affecting roughly 700,000 people per year. In studies with rabbits, fisetin has been shown to reduce stroke-induced behavioral deficits in patients with acute ischemic stroke. Further investigations of its actions in humans will need to be conducted to solidify fisetin's use in treating stroke.
3.What's the Best Age to Take Fisetin Supplements?
There isn't a definitive answer on when an adult should start taking fisetin supplements or any other dietary supplements that support healthy aging. Still, the consensus is that the sooner you look after your cellular health, the better.
Taking fisetin regularly can be particularly beneficial for young adults (18-35). During this period, the body undergoes many physical and cognitive demands due to work, study, and active lifestyles.
Middle-aged adults (35-60) who find this stage involves significantly balancing professional responsibilities and personal commitments, resulting in fluctuating energy levels. Some adults find that regular fisetin supplementation helps to maintain stable energy levels and focus.
As the body ages, it's even more important for older adults (60+) to maintain their overall health. Fisetin's benefits for cardiovascular health and cognitive support may contribute significantly to other healthy lifestyle choices like diet and exercise to maintain energy and sharpness.
4.How do I buy Fisetin Powder？
Buy Fisetin powder from a bulk supplement ingredient supplier at Sost biotech. Enhance your wellness with Fisetin Powder from www.sostceramide.com.
References
[1] https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(18)30373-6
[2] https://clinicaltrials.gov/ct2/show/NCT03430037
[3]https://www.sciencedaily.com/releases/2006/10/061017164401.htm
[4] Grynkiewicz G, Demchuk OM. New Perspectives for Fisetin. Front Chem. 2019;7:697.