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Can you use retinol and hyaluronic acid together?
2025-04-17
The synergistic effect of retinol and Hyaluronic Acid
Retinol: The anti-aging Powerhouse
Retinol works by accelerating skin cell turnover, stimulating collagen synthesis, and reducing the appearance of fine lines and wrinkles. It also helps fade hyperpigmentation and improve skin texture. However, its exfoliating properties can cause dryness, irritation, and sensitivity, particularly in individuals with reactive skin.

Hyaluronic Acid: The Ultimate Hydrator
HA is renowned for its ability to retain up to 1,000 times its weight in water, making it a cornerstone of hydration. It plumps the skin, improves elasticity, and strengthens the skin barrier. By replenishing moisture, HA counteracts retinol-induced dryness and irritation, creating a balanced skincare routine.
Synergy in Action
When combined, retinol and HA create a complementary relationship:
- Hydration + Cell Renewal: HA's moisturizing effects mitigate retinol's drying side effects, while retinol's exfoliation enhances HA's penetration .
- Collagen Boost: Retinol increases collagen production, and HA supports collagen stability, leading to firmer, smoother skin.
- Reduced Irritation: HA's anti-inflammatory properties calm skin sensitivity triggered by retinol.
How to Safely it into Your Skincare?
Product Selection
- Retinol: Start with low concentrations (0.1–0.3%) and gradually increase to 1% as tolerance builds. Look for stabilized formulas (e.g., retinol palmitate) to minimize irritation.
- Hyaluronic Acid: Opt for sodium hyaluronate, a water-soluble form, for optimal hydration. Pair it with humectants like glycerin for enhanced moisture retention.
Layering Techniques
- Cleanse Gently: Use a pH-balanced cleanser to avoid stripping the skin.
- Apply Retinol First: Apply retinol serum or cream to dry skin, allowing 10–30 minutes to absorb.
- Follow with Hyaluronic Acid: Layer HA serum or moisturizer to lock in hydration and reduce irritation.
- Seal with Moisturizer:Finish with a nourishing cream containing Ceramides or shea butter to protect the skin barrier.
Frequency and Timing
- Retinol: Begin with 2–3 times weekly and gradually increase to nightly use. Avoid daytime application due to photosensitivity.
- Hyaluronic Acid: Use daily, morning and night, to maintain hydratio.
Dos and Don'ts
- Do: Patch-test new products and introduce retinol slowly.
- Don't: Mix retinol with AHAs/BHAs (e.g., glycolic acid) or vitamin C, as this may increase irritation.
Expert Tip: Combine retinol with niacinamide (vitamin B3) to enhance barrier function and reduce redness.
Good Hyaluronic Acid Supplier
For high-quality hyaluronic acid solutions, Xi'an Sost Biotech stands as a leading manufacturer and supplier. Specializing in cosmetic ingredients, healthcare products, and plant extracts.

Contact us today to explore their comprehensive product range.
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References
- Procoal. (2021, June 22). How to Layer Hyaluronic Acid and Retinol.
- Frank Body. (2024, December 12). Can I Mix Hyaluronic Acid, Vitamin C, Retinol and Niacinamide?.
- SkinMedica. (n.d.). HA⁵® Hydra Collagen Replenish + Restore Hydrator.
- China Fruit Powder, Herb Medicine, Food Additives, Vegetable Powder Manufacturers and Factory - Xi'an Sost Biotech Co.,Ltd. (n.d.).
- Sost Biotech-Cosmetic Ingredients,Heathcare Product. (2021, February 22).
- Journal of Cosmetic Dermatology. (2023). Combined Effects of Retinol and Hyaluronic Acid on Skin Aging.