Cosmetic Raw Materials
what is Urolithin B?
Urolithin B is a naturally occurring substance produced in the gut microbiota through the processing of ellagic acid found in foods such as pomegranates and nuts. This definition reflects its “double appearance” – it is a plant-derived by-product and the microbial factory that makes it inside the body must function properly. When you eat foods high in ellagic tannins (e.g., pomegranates, strawberries, walnuts, and raspberries), these large polyphenol molecules are first broken down into ellagic acid by stomach acid and enzymes. However, ellagic acid has very low biological activity and is difficult for the body to absorb and use. Meanwhile, other types of intestinal microorganisms (e.g., Streptococcus gordonii) act as “alchemists,” primarily converting ellagic acid into coagulants such as fluids A, B, C, and D .
COA
| Analysis | Description | Test Method |
| Appearance | Off-white to yellowish powde | Complies |
| Identification | 1HNMR confirms to structure | Complies |
| Loss on drying | ≤ 0.5% | 0.08% |
| Ash | ≤ 0.5% | 0.23% |
| Purity (HPLC) | ≥98.0% | 99.71% |
What are the main functions of urolithin B?
1. Activate mitophagy and rearrange the cellular energy environment. The major biological function of urolithin B is the regulation of mitophagy. Mitophagy is an essential process for cells to clear damaged mitochondria and maintain homeostasis, and it is closely associated with aging, neurodegeneration, and autoimmune diseases.
2. Interaction between inflammation and immunomodulators . Inflammation is at the root of many diseases, and urolithin B exhibits a wide range of antitumor activities. The expression of pro-inflammatory cytokines was reduced at 100 μM for 24 h.
3. Maintain skeletal muscle mass and flexibility .
Sarcopenia is a major health problem in the elderly population. Studies have shown that urolithin B is a potent vascular remodeling agent. Urolithin B can induce muscle hypertrophy in rats and significantly reduce muscle weakness after spinal cord resection. This finding opens new avenues for the development of sports and musculoskeletal products for the elderly.
4. Brain protection and cognitive support .
It can also reduce tissue damage due to its antioxidant properties. In neurodegenerative models, urolithin B not only reduced the overproduction of microglia but also increased the expression of antioxidant enzymes involved in the Nrf2/ARE pathway, thereby decreasing the intracellular level of ROS. It has been shown to be associated with neurodegenerative and neurodegenerative diseases, such as Parkinson’s disease and Alzheimer’s disease.
2. Interaction between inflammation and immunomodulators . Inflammation is at the root of many diseases, and urolithin B exhibits a wide range of antitumor activities. The expression of pro-inflammatory cytokines was reduced at 100 μM for 24 h.
3. Maintain skeletal muscle mass and flexibility .
Sarcopenia is a major health problem in the elderly population. Studies have shown that urolithin B is a potent vascular remodeling agent. Urolithin B can induce muscle hypertrophy in rats and significantly reduce muscle weakness after spinal cord resection. This finding opens new avenues for the development of sports and musculoskeletal products for the elderly.
4. Brain protection and cognitive support .
It can also reduce tissue damage due to its antioxidant properties. In neurodegenerative models, urolithin B not only reduced the overproduction of microglia but also increased the expression of antioxidant enzymes involved in the Nrf2/ARE pathway, thereby decreasing the intracellular level of ROS. It has been shown to be associated with neurodegenerative and neurodegenerative diseases, such as Parkinson’s disease and Alzheimer’s disease.
Where is Urolithin B primarily used?
Research reagents and clinical trials
Currently, the main role of urolithin B is in the research phase. Research areas include the AMPK signaling pathway, the NF-κB inflammasome pathway, mitochondrial function, muscle damage, and muscle fatigue mechanisms. Its complex molecular targets and multidirectional regulatory properties make it an ideal molecular tool for mechanistic research.
Complementary Nutrition and Health Services
With increasing knowledge of the gut microbiota, urolithin B powder has emerged as a potential ingredient for next-generation healthy food development.
Anti-aging therapies: Evaluation of middle-aged and older adults with declining mitochondrial function.
Sports Nutrition Supplement: Helps muscles withstand and recover from workouts.
Treatment: Improves cognition with phosphatidylserine, DHA, and more.
Hormone Support: Improves insulin sensitivity and sugar and fat metabolism.
Currently, the main role of urolithin B is in the research phase. Research areas include the AMPK signaling pathway, the NF-κB inflammasome pathway, mitochondrial function, muscle damage, and muscle fatigue mechanisms. Its complex molecular targets and multidirectional regulatory properties make it an ideal molecular tool for mechanistic research.
Complementary Nutrition and Health Services
With increasing knowledge of the gut microbiota, urolithin B powder has emerged as a potential ingredient for next-generation healthy food development.
Anti-aging therapies: Evaluation of middle-aged and older adults with declining mitochondrial function.
Sports Nutrition Supplement: Helps muscles withstand and recover from workouts.
Treatment: Improves cognition with phosphatidylserine, DHA, and more.
Hormone Support: Improves insulin sensitivity and sugar and fat metabolism.
How to buy urolithin B?
Sost biotech urolithin B are available in larger or smaller packages, purity ≥98%. Note that the Sost can quantify pure Urolithin B raw materials, supported by comprehensive analytical assays such as HPLC, MS and NMR, and can provide customized solutions according to customer requirements. Connecting directly with a manufacturer gives enterprise customers flexible access to MOQ (minimum order quantity), faster order cycles, and expert sourcing advice.
Contact Email:ericyang@xasost.com
Contact Email:ericyang@xasost.com
Product Data Sheets
| Analysis | Description | Test Method |
| Appearance | Off-white to yellowish powde | Complies |
| Identification | 1HNMR confirms to structure | Complies |
| Loss on drying | ≤ 0.5% | 0.08% |
| Ash | ≤ 0.5% | 0.23% |
| Purity (HPLC) | ≥98.0% | 99.71% |
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