Active Pharmaceutical Ingredients
what is griffonia simplicifolia seed extract?
Ghana seed extract is a natural component extracted from the dried seeds of Griffonia simplicifolia, a leguminous shrub. Its main chemical component is 5-hydroxytryptophan (5-HTP), it is the precursor substance for the human body to synthesize serotonin (5-hydroxytryptamine).
Serotonin is a key neurotransmitter that regulates mood, sleep and appetite. Griffonia simplicifolia is native to West African countries such as Ghana, Ivory Coast and Togo in Africa.It ripens from December to February of the following year.
Serotonin is a key neurotransmitter that regulates mood, sleep and appetite. Griffonia simplicifolia is native to West African countries such as Ghana, Ivory Coast and Togo in Africa.It ripens from December to February of the following year.
COA
| Item | Specification | Result | Testing Method |
|---|---|---|---|
| Product Name | Griffonia Simplicifolia Seed Extract | ||
| Other Name | 5-hydroxytryptophan | ||
| Part Used | Seed | ||
| Assay | |||
| 5-HTP | 98% Min | 98.15% | HPLC |
| Physical & Chemical Control | |||
| Appearance | Off White Fine Powder | Complies | Visual |
| Odor | Characteristic | Complies | Organoleptic |
| Taste | Characteristic | Complies | Organoleptic |
| Sieve Analysis | 100% pass 80 mesh | Complies | 80 mesh screen |
| Loss on Drying | 7% Max. | 4.5% | 5g/100°C/2.5hrs |
| Ash | 9% Max. | 4.3% | 2g/525°C/3hrs |
| Arsenic (As) | 1 ppm Max | Complies | ICP-MS |
| Lead (Pb) | 2 ppm Max | Complies | AAS |
| Mercury (Hg) | 0.2 ppm Max. | Complies | ICP-MS |
| Cadmium (Cd) | 1.0 ppm Max | Complies | ICP-MS |
| Microbiological | |||
| Total Plate Count | 10000 cfu/g Max. | Complies | GB 4789.2 |
| Yeast & Mould | 100 cfu/g Max | Complies | GB 4789.15 |
| Coliforms | Negative | Complies | GB 4789.3 |
| Pathogens | Negative | Complies | GB 29921 |
| Conclusion | Complies with specification | ||
| Storage | In cool & dry place. Keep away from strong light and heat. | ||
| Shelf life | 2 years when properly stored. | ||
| Packing | 25KG/drum, Packed in paper-drums with two plastic-bags inside. |
What is Griffonia simplicifolia used for?
1. Stabilize emotions and resist anxiety
Clinical studies have shown that 5-HTP can alleviate mild depressive symptoms and anxiety by increasing serotonin levels.Insufficient serotonin is associated with low mood and irritability. Supplementing 5-HTP May help stabilize emotions.
2. Regulate sleep quality
Serotonin can be further converted into melatonin (a hormone that regulates sleep) in the human body.Appropriate supplementation of 5-HTP May shorten the time to fall asleep and improve the depth of sleep, especially for insomnia caused by stress or emotional problems.
3. Appetite suppression and weight management
Elevated serotonin levels can increase satiety and reduce the desire for high-sugar and high-fat foods.Some studies suggest that 5-HTP May assist in weight management by regulating appetite, but it should be combined with diet and exercise.
4. Antioxidation and neuroprotection
The extract of Ghana seeds contains polyphenols and has certain antioxidant capacity, which may reduce the damage of free radicals to nerve cells.Animal experiments have shown that its components may have a potential protective effect on neurodegenerative diseases such as Parkinson's disease.
5. Cardiovascular health support
Preliminary research has found that 5-HTP May indirectly support cardiovascular function by regulating vascular tension and lowering blood pressure, but more clinical data is needed for verification.
Clinical studies have shown that 5-HTP can alleviate mild depressive symptoms and anxiety by increasing serotonin levels.Insufficient serotonin is associated with low mood and irritability. Supplementing 5-HTP May help stabilize emotions.
2. Regulate sleep quality
Serotonin can be further converted into melatonin (a hormone that regulates sleep) in the human body.Appropriate supplementation of 5-HTP May shorten the time to fall asleep and improve the depth of sleep, especially for insomnia caused by stress or emotional problems.
3. Appetite suppression and weight management
Elevated serotonin levels can increase satiety and reduce the desire for high-sugar and high-fat foods.Some studies suggest that 5-HTP May assist in weight management by regulating appetite, but it should be combined with diet and exercise.
4. Antioxidation and neuroprotection
The extract of Ghana seeds contains polyphenols and has certain antioxidant capacity, which may reduce the damage of free radicals to nerve cells.Animal experiments have shown that its components may have a potential protective effect on neurodegenerative diseases such as Parkinson's disease.
5. Cardiovascular health support
Preliminary research has found that 5-HTP May indirectly support cardiovascular function by regulating vascular tension and lowering blood pressure, but more clinical data is needed for verification.
Who should not take 5 htp?
1. Pregnant and lactating women
At present, there is a lack of sufficient research to confirm the safety of Ghana seed extract for fetuses or infants. Its active ingredient, 5-hydroxytryptophan (5-HTP), may be transmitted through the placenta or breast milk, and the potential risks are unknown. Its use should be completely avoided.
2. Those taking antidepressants or central nervous system drugs
Antidepressants (such as SSRIs, SNRIs, MAOIs, etc.) :griffonia simplicifolia seed extract can increase serotonin levels. When combined with drugs, it may lead to "serotonin syndrome", which is characterized by high fever, convulsions and even coma. Sedative drugs (such as sleeping pills and anti-anxiety drugs) : 5-HTP May enhance the sedative effect, causing drowsiness or breathing difficulties. Parkinson's disease drugs (such as levodopa) : 5-HTP May interfere with drug metabolism and aggravate movement disorders.
3. People with bleeding disorders or abnormal coagulation function
5-HTP May inhibit platelet aggregation and increase the risk of bleeding, especially posing a greater threat to people who are taking anticoagulants (such as warfarin) or have hemophilia or thrombocytopenia.
4. Patients before and after surgery
Discontinuation is required two weeks before the operation to avoid an increased risk of intraoperative and postoperative bleeding.Postoperative recovery period also requires caution to prevent delayed wound healing.
5. Patients with autoimmune diseases
The extract of Ghana seeds may activate the immune system and aggravate the inflammatory response of diseases such as rheumatoid arthritis and lupus erythematosus.
At present, there is a lack of sufficient research to confirm the safety of Ghana seed extract for fetuses or infants. Its active ingredient, 5-hydroxytryptophan (5-HTP), may be transmitted through the placenta or breast milk, and the potential risks are unknown. Its use should be completely avoided.
2. Those taking antidepressants or central nervous system drugs
Antidepressants (such as SSRIs, SNRIs, MAOIs, etc.) :griffonia simplicifolia seed extract can increase serotonin levels. When combined with drugs, it may lead to "serotonin syndrome", which is characterized by high fever, convulsions and even coma. Sedative drugs (such as sleeping pills and anti-anxiety drugs) : 5-HTP May enhance the sedative effect, causing drowsiness or breathing difficulties. Parkinson's disease drugs (such as levodopa) : 5-HTP May interfere with drug metabolism and aggravate movement disorders.
3. People with bleeding disorders or abnormal coagulation function
5-HTP May inhibit platelet aggregation and increase the risk of bleeding, especially posing a greater threat to people who are taking anticoagulants (such as warfarin) or have hemophilia or thrombocytopenia.
4. Patients before and after surgery
Discontinuation is required two weeks before the operation to avoid an increased risk of intraoperative and postoperative bleeding.Postoperative recovery period also requires caution to prevent delayed wound healing.
5. Patients with autoimmune diseases
The extract of Ghana seeds may activate the immune system and aggravate the inflammatory response of diseases such as rheumatoid arthritis and lupus erythematosus.
where to buy griffonia simplicifolia seed extract?
Buy griffonia simplicifolia seed extract - Contact SoST Biotech Factory for:
✓ Bulk discounts (MOQ 25kg)
✓ FREE 20g samples with COA
✓ OEM services/Specification Customization
Email:ericyang@xasost.com
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Product Data Sheets
| Items | Specification | Results |
| Color | White To light yellow | white |
| Appearance | Powder Or crystal | Powder |
| Oder | Characteristic | Characteristic |
| Total Glucoside Content/% | ≥80 | 85.64 |
| PH | 4.5-7.0 | 5.25 |
| Burned residue/% | ≤1 | 0.09 |
| Loss on Drying/% | ≤6 | 2.45 |
| Pb/(mg/kg) | ≤1 | ＜1 |
| Lead(Pb)/(mg/kg) | ||
| Arsenic/(mg/kg) | ≤1 | ＜1 |
| methanol/(mg/kg) | ≤ 200 | 30 |
| ethanol/(mg/kg) | ≤ 5000 | 1030 |
| Microbiological Analysis： | ||
| TABC | ＜1000cfu/g | ＜1000 cfu/g |
| Yeast/Mold | ＜100 cfu/g | ＜100 cfu/g |
| Shelf Life: | Three Years | |