Fisetin Powder Bulk

Fisetin powder bulk is a natural flavonol that was first isolated from plants of the Anacardiaceae family, hence its name. Its molecular skeleton belongs to polyphenols, with a chemical formula of C₁₅H₁₀O₆, CAS No. 528-48-3, and is a pale yellow to off-white crystalline powder. It is insoluble in water, but easily soluble in polar solvents such as acetone, ethanol, and dimethyl sulfoxide. In nature, foods such as strawberries, apples, onions, cucumbers, and grape skins all contain trace amounts of Fisetin, but the total amount is extremely low - Japanese scholars have calculated that the average daily dietary intake per person is only about 0.4 mg. If you want to play a clear role in scientific research or functional foods, you usually need a "Fisetin powder" raw material with a purity of ≥98%, which is obtained through processes such as crude extraction of Cotinus coggygria or strawberry, chromatography refining, and recrystallization, and then qualified by HPLC external standard method before it can enter downstream applications.

One of the common pathological features of neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD) is chronic neuroinflammation. Fisetin reduces the release of proinflammatory cytokines TNF-α, IL-1β, and IL-6 by inhibiting the NF-κB signaling pathway, thereby reducing the "secondary blow" caused by excessive activation of microglia.

Animal experiments have shown that Fisetin can activate the ERK/CREB pathway, increase the expression of synaptic proteins synapsin I and PSD95, and enhance long-term potentiation (LTP), which ultimately manifests as an improvement in learning and memory consolidation ability.

In AD transgenic model mice, continuous administration of Fisetin powder 25 mg/kg for 3 months can significantly reduce the area of Aβ42 plaques in the hippocampus and reverse memory deficits.

Fisetin has been shown to upregulate SIRT1 expression, enhance mitochondrial function, and delay cell aging. This mechanism is not only related to neuroprotection, but is also considered a new target for anti-aging research.

Low dose (≤25 mg/portion) can be used as a "memory support" formula ingredient and added to energy bars and ready-to-drink functional beverages.

Using its strong antioxidant properties, fisetin powder can be added to creams and essences to combat skin oxidative stress and reduce photoaging.

The derivative CMS121 with fisetin as the parent core has been launched in the United States for the treatment of AD in Phase I trials and may enter the prescription drug market in the future.

High-purity fisetin powder is widely used in cell oxidative stress models and animal behavioral experiments to study the mechanisms of Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS).

Preliminary studies have found that fisetin powder can fight chronic traumatic encephalopathy (CTE) caused by repeated concussions by inhibiting neuroinflammation and promoting neurotrophic factors.