Active Pharmaceutical Ingredients
what is Citrine Pleurotus Extract Ergothioneine?
Citrine Pleurotus Extract is a rare edible mushroom with a golden color and a "forest gold" aura. Its cap contains the highest known naturally occurring concentration of ergothioneine (EGT), the "longevity vitamin."
COA of 5% Polysaccharide Ergothioneine
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Items |
Standards |
Results |
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Physical Analysis |
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Description |
Light Yellow Powder |
Complies |
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Assay |
L-Ergothioneine ≥ 5.0% |
5.06% |
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Total Nucleotides ≥ 10mg/g |
11.25mg/g |
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Total Amino Acids ≥ 10.0% |
11.175% |
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Mannitol ≥ 5.0% |
5.16% |
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Mesh Size |
95 % pass 80 mesh |
Complies |
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Ash |
≤ 5.0% |
3.00% |
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Loss on Drying |
≤ 5.0% |
4.60% |
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Chemical |
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Pb |
≤ 2ppm |
Not detected |
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As |
≤ 2ppm |
Not detected |
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Cd |
≤ 2ppm |
Not detected |
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Hg |
≤ 2ppm |
Not detected |
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Microbiological Analysis |
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Total Plate Count |
≤ 1000cfu/g |
Complies |
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Yeast&Mold |
≤ 100cfu/g |
Complies |
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E.coil |
Negative |
Negative |
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Salmonella |
Negative |
Negative |
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Shelf Life |
24 months under the conditions below, no antioxidant used |
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Package&Storage |
Standard packed in fiber-drum and two plastic bags inside |
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N.W: 25kgs. I.D. 35 x H51 cm; |
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Store in a cool,dry place away from Moisture, Light, Oxygen |
What is the strength of ergothioneine in Pleurotus eryngii?
1. Content Ceiling: Undisputed Natural "Golden Mine"
Multiple independent tests have shown that the average ergothioneine content in dried fruiting bodies of Pleurotus eryngii reaches 2.7 mg/g, significantly higher than that found in common edible fungi such as Ganoderma lucidum, Hericium erinaceus, and Shiitake mushrooms. Under identical extraction conditions, its yield is 1.8 times higher than that of Pleurotus ostreatus and 3.2 times higher than that of Agrocybe oleracea, earning it the nickname "a natural EGT deposit."
2. Target: A "cruise missile" that reaches mitochondria and the cell nucleus
Research from the Johns Hopkins University School of Medicine indicates that ergothioneine is the only long-lasting antioxidant in the human body that can precisely enter the mitochondria and cell nucleus via a dedicated transporter protein, OCTN1. It directly neutralizes ROS within the mitochondrial matrix, protecting mtDNA and blocking free radical damage to the electron transport chain, thereby delaying cellular aging at its source. Compared to vitamin C and vitamin E, which can only act as "passive scavengers" outside the cell, EGT acts more like a cruise missile: precise, long-lasting, and recyclable.
3. Multi-Pathway Synergy: Not Just "Working Alone," but "Leading a Team"
Recent cell experiments have revealed that Pleurotus ostreatus extract ergothioneine significantly upregulates the activities of glutathione peroxidase (GPx) and catalase (CAT), activating the endogenous antioxidant network. This means that while it scavenges free radicals, it also boosts the skin's "employees," keeping the body's antioxidant system in a 24-hour rotation.
4. Mildness and Stability: A Natural Alkali and Enzyme-Resistant
EGT maintains an active half-life of >90% at pH 3–9 and temperatures up to 80°C. Synthetic antioxidants like ferulic acid and phloretin are easily degraded in alkaline environments or in the presence of metal ions. For creams and serums requiring high-temperature emulsification and pH adjustment, Pleurotus ostreatus EGT is a formula-friendly star.
Multiple independent tests have shown that the average ergothioneine content in dried fruiting bodies of Pleurotus eryngii reaches 2.7 mg/g, significantly higher than that found in common edible fungi such as Ganoderma lucidum, Hericium erinaceus, and Shiitake mushrooms. Under identical extraction conditions, its yield is 1.8 times higher than that of Pleurotus ostreatus and 3.2 times higher than that of Agrocybe oleracea, earning it the nickname "a natural EGT deposit."
2. Target: A "cruise missile" that reaches mitochondria and the cell nucleus
Research from the Johns Hopkins University School of Medicine indicates that ergothioneine is the only long-lasting antioxidant in the human body that can precisely enter the mitochondria and cell nucleus via a dedicated transporter protein, OCTN1. It directly neutralizes ROS within the mitochondrial matrix, protecting mtDNA and blocking free radical damage to the electron transport chain, thereby delaying cellular aging at its source. Compared to vitamin C and vitamin E, which can only act as "passive scavengers" outside the cell, EGT acts more like a cruise missile: precise, long-lasting, and recyclable.
3. Multi-Pathway Synergy: Not Just "Working Alone," but "Leading a Team"
Recent cell experiments have revealed that Pleurotus ostreatus extract ergothioneine significantly upregulates the activities of glutathione peroxidase (GPx) and catalase (CAT), activating the endogenous antioxidant network. This means that while it scavenges free radicals, it also boosts the skin's "employees," keeping the body's antioxidant system in a 24-hour rotation.
4. Mildness and Stability: A Natural Alkali and Enzyme-Resistant
EGT maintains an active half-life of >90% at pH 3–9 and temperatures up to 80°C. Synthetic antioxidants like ferulic acid and phloretin are easily degraded in alkaline environments or in the presence of metal ions. For creams and serums requiring high-temperature emulsification and pH adjustment, Pleurotus ostreatus EGT is a formula-friendly star.
How does it fight aging both inside the body and on the surface of the skin?
1. Food Additive
Anti-photoaging: A randomized, double-blind trial showed that daily oral administration of 10 mg of Pleurotus erythematosus EGT for 8 weeks reduced UVB-induced erythema by 28% and epidermal water loss by 21%, effectively providing a built-in SPF "internal filter."
Brightening and Skin Tone: Citrine Pleurotus Extract EGT inhibits tyrosinase activity, downregulates MITF signaling, and reduces melanosome transport. It is particularly effective for the "dullness + dark spots" combination common in Asian women.
Collagen Protection: EGT blocks overexpression of MMP-1 and MMP-3, protecting types I and III collagen and delaying facial sagging.
2. Skin Topical Application
Transdermal Absorption: The OCTN1 transporter is expressed in both keratinocytes and fibroblasts. Citrine Pleurotus Extract EGT can be detected in the dermis 2 hours after topical application, with a cumulative penetration of 18.7 µg/cm² over 24 hours.
Instant soothing: 4 ppm of Pleurotus erythrorhizome EGT can inhibit the release of TNF-α and IL-6 inflammatory factors within 30 minutes, alleviating the redness and discomfort associated with "stay-up-night face" and "mask face."
Long-lasting wrinkle relief: After 28 days of using 0.1% EGT cream, participants experienced an average 12.4% reduction in crow's feet volume and a 9.8% increase in skin elasticity.
Anti-photoaging: A randomized, double-blind trial showed that daily oral administration of 10 mg of Pleurotus erythematosus EGT for 8 weeks reduced UVB-induced erythema by 28% and epidermal water loss by 21%, effectively providing a built-in SPF "internal filter."
Brightening and Skin Tone: Citrine Pleurotus Extract EGT inhibits tyrosinase activity, downregulates MITF signaling, and reduces melanosome transport. It is particularly effective for the "dullness + dark spots" combination common in Asian women.
Collagen Protection: EGT blocks overexpression of MMP-1 and MMP-3, protecting types I and III collagen and delaying facial sagging.
2. Skin Topical Application
Transdermal Absorption: The OCTN1 transporter is expressed in both keratinocytes and fibroblasts. Citrine Pleurotus Extract EGT can be detected in the dermis 2 hours after topical application, with a cumulative penetration of 18.7 µg/cm² over 24 hours.
Instant soothing: 4 ppm of Pleurotus erythrorhizome EGT can inhibit the release of TNF-α and IL-6 inflammatory factors within 30 minutes, alleviating the redness and discomfort associated with "stay-up-night face" and "mask face."
Long-lasting wrinkle relief: After 28 days of using 0.1% EGT cream, participants experienced an average 12.4% reduction in crow's feet volume and a 9.8% increase in skin elasticity.
Where to buy Citrine Pleurotus Extract Ergothioneine?
Sost Biotech is a manufacturer of Citrine Pleurotus Extract Ergothioneine.To facilitate your sales and production, we can customize mushroom extract formula products. You will need to provide detailed ratios or let our R&D team create a unique formula for you.
Our advantages
1. Free samples can be provided upon your request.
Our advantages
1. Free samples can be provided upon your request.
2. Production capacity: 20 tons/month.
3. The factory covers an area of 7,000 square meters and has 4 Ph.D. technical engineer.
4. Transportation method: express, air transport, sea transport
5. Quality control: 3rd party laboratory testing by Eurofins, SGS, BV etc.
6. 24 hours and 7 days full time standing-by services.
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Product Data Sheets
| Analysis | Description | Test Method |
| Appearance | Orange-Yellow Powder | Visual |
| Odor | Characteristic | Nasil |
| Identification | Conform with reference sample | HPLC |
| Mesh Size | 100% pass 80 mesh | CP2020 |
| Moisture Content | ≤ 1.0% | GB5009.3-2016 |
| Residue on Ignition | ≤ 0.5 % | CP2020 |
| Heavy Metals | ≤ 10 ppm | CP2020 |
| Arsenic (As) | ≤ 1.5 ppm | BS EN ISO17294-2 2016 2016 |
| Lead (Pb) | ≤ 2 ppm | BS EN ISO17294-2 2016 |
| Cadmium（Cd） | ≤1ppm | BS EN ISO17294-2 2016 |
| Mercury （Hg） | ≤1ppm | BS EN ISO17294-2 2016 |
| Methyl alcohol | 30ppm （Eurofins：LOQ ） | CP2020 |
| N,N-Dimethylformamide | 880ppm （Eurofins：LOQ ） | CP2020 |
| Total Plate Count | ≤10000 cfu/g | ISO 4833- 1:2013 |
| Yeast and Mold | ≤100 cfu/g | ISO 21527-2:2008 |
| Escherichia Coli | < 10cfu/g | ISO 16649-2:2001 |
| Salmonella/25g | Absent | ISO 6579-1:2017 |
| Effective constituent | Curcumin≥98% | HPLC |
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