NRCL Nicotinamide Riboside Chloride Powder CAS 23111-00-4

Nicotinamide Riboside Chloride Powder (NR-Cl) is a member of the vitamin B3 family. It is chemically derived from nicotinamide and ribose linked by a β-1,4-glycosidic bond, then salted with a molecule of hydrochloric acid. This powder is typically white to off-white, hygroscopic, and water-soluble, with a purity of ≥98%. Its solubility in water at 25°C can reach over 50 mg/mL, making it easy to formulate into various dosage forms, including capsules, tablets, and solid beverages.

Neuroprotection and Cognitive Recovery
I have energy deficits very easily. NR-Cl increases neuronal NAD+, promotes PGC-1α-mediated mitochondrial biogenesis, and inhibits PARP hyperactivity, reducing apoptosis after ischemia-reperfusion. In one report, NR-Cl (250 mg daily) for 16 weeks in adults with mild cognitive impairment (MCI) showed a 0.25 SD improvement in total memory scores and an increase in Aβ42/40 ratio in cerebrospinal fluid, suggesting s Alloz may affect disease progression.

Exercise and Muscle Repair
Skeletal muscle is an energy-intensive tissue, and NAD+ utilization increases dramatically after exercise. NR-Cl can rapidly compensate for this deficiency by activating the SIRT1-AMPK axis, promoting PGC-1α expression, and increasing mitochondrial density and the amount of oxidative myofibers.

Immune modulation and antimicrobial effects
NAD+ is the “fuel” used by the PARP family to repair virus-induced DNA damage. By maintaining the NAD+ pool, NR-Cl increases the secretion of cytokines such as IFN-γ and TNF-α, and promotes the anti-inflammatory response in macrophages.

After oral administration of NR-Cl(Nicotinamide Riboside Chloride), a "nucleoside green channel" in the small intestine allows NR-Cl to enter the bloodstream without being unpacked, with minimal loss during its initial passage through the liver.

Nicotinamide riboside kinase (NRK) lurks in the cytoplasm, attaching a phosphate cap to NR-Cl, transforming it into NMN. NMN is then transported into the mitochondria or nucleus, where it combines with ATP and transforms into NAD⁺. The entire process requires only two steps, eliminating a rate-limiting enzyme compared to the traditional B3 "niacin → NAD⁺" or "nicotinamide → NAD⁺" pathways, doubling the speed.

Once NAD⁺ arrives, it first activates a group of "longevity proteins" called Sirtuins:
SIRT1 deacetylates "aging switches" like p53 and NF-κB in the cell nucleus, keeping the DNA repair team on 24-hour standby;
SIRT3 "unblocks" the enzymes responsible for burning fat in the mitochondria, giving the mitochondria a new engine;
SIRT7, stationed in the nucleolus, regulates the ribosome factory, ensuring a stable protein supply chain.

NR-Cl, by replenishing NAD⁺, supports PARP repair while preventing overconsumption. It can also indirectly inhibit CD38 activity, reducing immune aging.